New Zealand Pine Extracts:
Enzogenol


The World's Only Full-Spectrum Antioxidant Supplement

In recent years, the popular and scientific press has been filled with reports of the harmful health effects caused or aggravated by free radicals and of the protective and regenerative effects of antioxidants, the body's main defense against free-radical damage. But what exactly are free radicals and what sort of damage do they cause?

The Free Radical Story

Free radicals are molecules containing an atom with an unpaired electron in its outer shell, making the molecule highly reactive. They are formed naturally in the body--for example, as byproducts of normal metabolism, by the breakdown of bacteria by white blood cells, or by enzymatic reactions; they are also formed, in ever-increasing numbers, outside the body by pollution, radiation, cigarette smoke, motor vehicle emissions, and many other processes. These environmental free radicals then enter the body through the skin, respiration, and other means.

Whether formed endogenously or exogenously, once in our bodies, these unstable free radicals rob electrons from other molecules to make themselves more stable. In the process, they often cause damage to the body's cells and metabolic processes and many times turn the molecules they have attacked into free radicals themselves. Those molecules, now missing an electron and highly reactive, rob electrons from other molecules, and a chain reaction occurs. This process is called oxidation. It happens all the time in our bodies. In fact, it is estimated that every cell in our body is attacked by free radicals thousands of times a day.

The Body's Defense Against Free Radical Damage

Left unchecked, oxidation can result in death. Fortunately, the body is able to curb free-radical damage by producing antioxidant molecules and enzymes. Their purpose is to neutralize oxidizing free radicals by donating an electron to them or robbing one from them. The body's arsenal of antioxidants appears to be sufficient for keeping oxidation in check in children and in youth, but once we reach our twenties, the effectiveness of the body's antioxidant defense mechanisms appears to lessen, and free radicals are given greater rein to do damage.¹ The results appear to be, that many of the diseases we associate with aging, including coronary heart disease, cancer, skin damage, Alzheimer's disease, strokes, and rheumatoid arthritis are from free-radical damage.¹

Our prognosis need not be bleak, however. Plants, like humans, produce antioxidants for their own natural defense mechanisms. So, growing all around us are sources of antioxidants that can be ingested to augment our bodies natural supply. Indeed, researchers believe that increased dietary intake of antioxidants can slow the process of free-radical damage and associated diseases.¹ Although fruits and vegetables contain the greatest amount of antioxidants in nature, their effectiveness as dietary antioxidants is diminished by four factors: (1) the concentrations of the different types of antioxidants in the plant tissues vary widely, (2) ripeness, storage, and growing conditions affect these concentrations, (3) few people ingest enough fruits and vegetables daily for optimum free-radical neutralization, and (4) dietary antioxidants are used up quickly by the body, requiring constant replenishment. For all of these reasons, researchers turned from fruits and vegetables to dietary supplementation in their search for the best way to supply the body with the antioxidants it needs.

The Road to EnzogenolT

In the 1950s, researchers isolated oligophenolic compounds (OPCs), which were the most potent antioxidants yet discovered, from pine bark. At the forefront of nutraceutical research for many years, the OPCs derived from the bark of the Pinus maritima tree, have received the most scientific validation to date.

Enzogenol Trade Mark

Still searching for the best possible source of antioxidants, Dr. Kelvin Duncan and his associates at the University of Canterbury in New Zealand isolated an even more effective OPC product in the mid 1990s. This product, which they called Enzogenol, is derived from several layers of the bark of the Pinus radiata tree, which is grown on subalpine tree forests in New Zealand in the complete absence of pesticides and chemical fertilizers, in air that is free from pollution.

With a unique, patent-pending process that uses only pure deionized water rather than chemical solvents (which can leave toxic residues in the product) to extract the components of the bark, they were able to harvest the purest and most complete complex of antioxidants ever found in a dietary supplement. So far, over 30 components have been positively identified in Enzogenol, but it is believed that there are many more.¹ Included in the complex are a number of significant groups of antioxidants that are lost in extraction processes that use chemical solvents. With such a wide array of bioflavonoids, monomeric and oligomeric proanthocyanidins, organic acids, flavonoid glycosides, esters, and other plant compounds, Enzogenol's antioxidant capabilities far surpass those of other antioxidant supplements.

Positive Effects Seen in Laboratory Studies and Anecdotal Reports

To test the health effects of Enzogenol, Dr. Duncan and his colleagues fed one group of mice commercial mouse pellets mixed with a normal human equivalent dose of Enzogenol for their entire lifetime. They fed another group the commercial mouse pellets mixed with Enzogenol at a dose that was 100 times the normal human dose for their entire lifetime, and they fed a third group (the control group) the mouse pellets without Enzogenol added for their entire lifetime. The researchers found that the mice fed Enzogenol lived significantly longer than the control group and developed significantly fewer tumors (only 13% of the mice fed the 100x dose developed any tumors, whereas 50% of the control group did). Further, the tumor incidence rate was found to be dependent on the dosage.¹

When independent, "blind" observers were asked to compare the general condition of the groups of mice, they invariably ranked the mice fed the dose that was 100 times the normal human equivalent as having the best condition, ranked the other Enzogenol group next, and ranked the control group as having the worst condition. The researchers attributed the better condition of the mice fed Enzogenol to the protective effect of antioxidants. They also noted the possibility of improved metabolism, citing evidence that antioxidants assist the body in the uptake of nutrients.¹

Although clinical studies have not yet been published, people taking Enzogenol have reported, among other benefits, a heightened feeling of well-being, reduced pain and stiffness, higher energy levels, increased alertness, fewer allergic reactions, a reduction in migraines, less depression, and better sleep. In almost all cases, when Enzogenol usage was discontinued, the symptoms returned. There has been no evidence of negative side effects.¹

Informative References:

1. Duncan, K., Fighting Free Radicals: The Enzogenol Story. Christchurch, NZ: The Pacific Scientific Press, 1998.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

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