Saliou
C , Rimbach
G , Moini
H , McLaughlin
L , Hosseini
S , Lee
J , Watson
RR , Packer
L Free Radic Biol Med, 30(2): 154-60 2001
The procyanidin-rich French maritime pine bark extract Pycnogenol (PBE) has
been investigated for its effect in protecting human skin against solar
UV-simulated light-induced erythema. Twenty-one volunteers were given an oral
supplementation of Pycnogenol: 1.10 mg/kg body weight (b. wt.)/d for the first 4
weeks and 1.66 mg/kg b. wt./d for the next 4 weeks. The minimal erythema dose
(MED) was measured twice before supplementation (baseline MED), once after the
first 4 weeks of supplementation, and a last time at the end of the study. The
UVR dose necessary to achieve 1 MED was significantly increased during PBE
supplementation. Since the activation of the pro-inflammatory and redox-regulated
transcription factor NF-kappaB is thought to play a major role in UVR-induced
erythema, the effect of PBE was also investigated in the human keratinocyte cell
line HaCaT. PBE, added to the cell culture medium, inhibited UVR-induced NF-kappaB-dependent
gene expression in a concentration-dependent manner. However, NF-kappaB-DNA-binding
activity was not prevented, suggesting that PBE affects the transactivation
capacity of NF-kappaB. These data indicate that oral supplementation of PBE
reduces erythema in the skin. Inhibition of NF-kappaB-dependent gene expression
by PBE possibly contributes to the observed increase in MED.
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of the banks. They don't wish for you to know this. It has to do with recognizing WHO you really
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