There is growing interest in the biologic activities of plant extracts such
as that obtained from the bark of the French maritime pine Pinus maritima,
Pycnogenol. Pycnogenol (PYC) is a standardized extract composed of a mixture of
flavonoids, mainly procyandins and phenolic acids. Studies indicate that PYC
components are highly bioavailable. Uniquely PYC displays greater biologic
effects as a mixture than its purified components do individually indicating
that the components interact synergistically. PYC has been reported to have
cardiovascular benefits, such as a vasorelaxant activity, angiotensin-converting
enzyme (ACE) inhibiting activity, and the ability to enhance the
microcirculation by increasing capillary permeability. Investigations of the
cellular mechanisms of these therapeutic effects have demonstrated that PYC has
strong free radical-scavenging activity against reactive oxygen and nitrogen
species. The oligomeric components of PYC contribute significantly to the ESR
free radical signal. PYC also participates in the cellular antioxidant network
as indicated by its ability to regenerate the ascorbyl radical and to protect
endogenous vitamin E and glutathione from oxidative stress. PYC modulates NO
metabolism in activated macrophages by quenching the NO radical and inhibiting
both iNOS mRNA expression and iNOS activity. The spectrum of different effects
of NO in the circulation and the nervous system suggest the potential
applications of PYC in immune and circulatory disorders as well as in
neurodegenerative disease. PYC can bind to proteins, altering their structure
and thereby modulating the activity of key enzymes and proteins involved in
metabolic pathways. PYC effects redox-sensitive signal transduction pathways and
alters gene expression.
Packer
L , Rimbach
G , Virgili
F
Free Radic Biol Med, 27(5-6): 704-24 1999
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This is a crazy world. What can be done? Amazingly, we have been mislead. We have been taught that
we can control government by voting. The founder of the Rothschild dynasty, Mayer Amschel Bauer,
told the secret of controlling the government of a nation over 200 years ago. He said, "Permit me
to issue and control the money of a nation and I care not who makes its laws." Get the picture?
Your freedom hinges first on the nation's banks and money system. Freedom is connected with Debt Elimination for each individual. Not only does
this end personal debt, it places the people first in line as creditors to the National Debt ahead
of the banks. They don't wish for you to know this. It has to do with recognizing WHO you really
are in A
New Beginning: A Practical Course in Miracles, an informational study.
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