Petrassi
C , Mastromarino
A , Spartera
C
Phytomedicine, 7(5): 383-8 2000
The aim of our study was to investigate the efficacy of Pycnogenol - a French
maritime pine bark extract - in the treatment of chronic venous insufficiency (CVI).
The study consisted of a double-blind phase - in which 20 patients were
recruited and randomly treated with placebo or Pycnogenol (100 mg 2 3/day for 2
months) - and an open phase - in which other 20 patients were treated with
Pycnogenol at the same dose schedule. In total, 40 patients were enrolled; 30 of
them were treated with Pycnogenol and 10 with placebo. Pycnogenol significantly
improved the legs' heaviness and subcutaneous edema; the venous pressure was
also significantly reduced by the Pycnogenol treatment, thus adding further
clinical evidence to its therapeutic efficacy in patients with CVI. Pycnogenol
was effective, probably by either stabilizing the collagenous subendothelial
basal membrane or scavenging the free radicals, or by a combination of these
activities. Clinically, capillary leakage, perivascular inflammation and
subcutaneous edema were all reduced. The safety of use of Pycnogenol is
demonstrated by the lack of side effects or changes in blood biochemistry and
hematologic parameters. Pycnogenol can be therefore recommended both for
prevention and treatment of CVI and related veno-capillary disturbances.
Pycnogenol in chronic venous insufficiency.
Arcangeli
P
Fitoterapia, 71(3): 236-44 2000
Forty patients with chronic venous insufficiency (CVI) and varices of the
legs were selected and double-blindly randomly assigned to a treatment with
Pycnogenol (French maritime pine bark extract), 100 mg x 3/day or a placebo for
2 months, according to a double-blind experimental design. The effects of the
treatment were evaluated by scoring the symptomatology with a semi-quantitative
scale, and the venous blood flow by means of a hand-held Doppler ultrasound. The
tolerability was evaluated by recording the adverse effects and by means of
hematology and blood chemistry parameters, before and at the end of the
treatment. Pycnogenol treatment induced a significant reduction in subcutaneous
edema as well as heaviness and pain in the legs, on both after 30 and 60 days,
the evaluation time periods. Approximately 60% of patients treated with
Pycnogenol(R) experienced a complete disappearance of edema (the most rapidly
disappearing symptom) and pain at the end of the treatment, while almost all the
patients reported a reduction in leg heaviness which disappeared in
approximately 33% of patients. These changes were statistically significant. No
effect was observed in the placebo-treated subjects. No effect on the venous
blood flow was observed in either of the experimental groups.
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